Volume 1, Issue 2, November 2013, Page: 21-27
Mixed Ligand Complexes of Gold (III) with Some Amino Acids and Dithiocarbamates or Dithiophosphates
Mikkat Zaghlool Hamdi., Department of Chemistry , College of science University of Mosul, Mosul, Iraq.
Ihsan Abdulghani Mustafa, Department of Chemistry , College of science University of Mosul, Mosul, Iraq.
Received: Oct. 29, 2013;       Published: 30, 2013
DOI: 10.11648/j.sjac.20130102.13      View  3597      Downloads  264
Complexes of the type [Au(L)(L-orL=)]Cl were prepared [L= deprotonated glycine (Gly), Alanine (Ala), Valine(Val) or Methionine (Met), L- = N-Methylcyclohexyldithiocarbamate(N-MeCHdtc) or Benzyldithiocarbamate(Bzdtc) anion and L= =0,0-Dipropyldithiophosphate (DiPrdtp) or 0,0- Dibenzyldithiophosphate (DiBzdtp) anion. The prepared complexes were characterized by elemental analysis, molar conductivity, IR and UV-Vis spetra, magnatic susceptibility and (1H-nmr) for some of the complexes. The gold(III) complexes were all square planar with the dithiocarbamates or dithiophosphates acted as bidentate ligands coordinated through the two sulfur atoms and the aminoacid anions coordinated through N and O except for the methionine ligand which coordinate through S and N atoms.
Amino Acid Complex, Dithiocarbamates, Dithiophosphates
To cite this article
Mikkat Zaghlool Hamdi., Ihsan Abdulghani Mustafa, Mixed Ligand Complexes of Gold (III) with Some Amino Acids and Dithiocarbamates or Dithiophosphates, Science Journal of Analytical Chemistry. Vol. 1, No. 2, 2013, pp. 21-27. doi: 10.11648/j.sjac.20130102.13
S.J. Price, P.J.Sadler "Gold drugs in frontiers in bioinorganic chemistry", Xavier, A.V., (Ed), VC+1 Publ. Weinhein, pp376-388(1986).
O.M.Dhubhghaill and P.J. Sadler "Gold complexes in chemotherapy in metal complexes in chemotherapy", B.K. keppler (Ed) VCH Publ. Weinhein, pp 225-250(1993).
K.C.Dash and H.Schmidbar, "Metal ions in biological systems", H. Sigel, Ed., Marcel Dekker, New York, p.179ff(1982).
C.F.Shaw," Progress in chemistry, biochemistry and technology", Schmidbau r, H., Ed., Wiley, New York, P.259ff(1999).
P.J.Sadler and R.E.Sue, "The chemistry of gold drugs", B.K. Keppler (Ed) VCH Publ. Weinhein, PP 115-127(1994).
V.Mariana "Structural studies of metal complexes with aminoacids and biomarkers for use in diagnostic", Ph.D thesis, Babes-Bolyai University, Romania,(2012) website www.ubbcluj.ro
H.C.Freeman, "Metal complexes of aminoacids and peptides,inorganig biochemistry", Eichhorn,G.L.,Ed., Elsevier, Scientific, Amsterdam,(1),PP 121-166(1973).
H.Hossain, M.S.Islam,A. Alam,T. Saltan,"Synthsis, physicochemical studies and antimicrobial screening of metal complexes of Fe(III) and Au(III) with aminoacids", Inter.J.Sci and Tech. Res.,2,7,(2013).
N. Manav, A. K. Mishra and N.K. Kaushik," In vitroantitumour and antibacterial studies of some Pt(IV) dithiocarbamate complexes", Spectrochim Acta. Part A Molecular and Biomolecular spectroscopy, 65(1),32 (2005).
G.Hogrth,"Metal dithiocarbamate complexes: chemistry and biological activity", Mini Rev. Med. Chem., 12(12), pp1202-1215(2012).
K. Rajasekar,R.T. Ramchandramoorthy and A. Paulraj," Microwave assisted synthesis, structural characterization and biological activities of 4-aminoantipyrine and thiocyanate mixed ligand complexes", Res.J. Pharmaceutical Sci., 1(4), pp 22-27(2012).
A. Vogel, "A text book of practical organic chemistry". ELBS: London, pp499–501(1968).
F.F.Jian, Q.Hao, X.Hang,L.Lu,X.Wang, "Structure of bis(o,o- diisopropyldithiophosphato-S,S′)(1,10-phenanthroline N1,N10) zinc(II) complex, [Zn(phen)(S2P(OiPr)2)2]", J.Chem.Crytallog. 30, 7, pp469-472(2000).
W.J. Geary, "The use of conductivity measurements in organic solvents for characterization of coordination compounds", Coord. Chem. Rev., 7, 81(1971).
E.A. Abdalrazaq, N.H. Buttrus and A.A. Abd Al-Rahman, " Synthesis and characterization of gold(iii) complexes with bis-(1,4-sodium thioglycolate) butane ligand", Asian J. Chem., 22, (3), pp 2179-2186 (2010).
J.M. Tunney, A.J. Blake, E.S.Davies, J. Mcmater, C.Wilson and C.D. Garner, "Synthesis and structure of gold(III) complexes of asymmetric dithiolene ligands "Polyhedron., 25, 2,P. 591, (2006).
A. Manohar, K. Ramalingam, and K. Karpagavel, "Mixed ligand complexes involving bis(dithiocarbamato)nickel(ii) and phosphorus donors: synthesis, spectral, thermal studies and bvs investigations" Inter.J. Chem.Tech. Res., 4, (4), pp1383-1391, (2012).
A. J. Odola and J. A.O. Woods," Synthesis, characterization and antimicrobial activity studies of new nickel(ii) mixed ligand complexes of disubstituted dithiocarbamates with ethylsalicylaldiminate" Scholars Research Library, Archives of Applied Science Research, 3 (4)pp 463-470,(2011).
L. Giovagnini, C. Marzano, F.Bettio and D.Fregona, "Mixed complexes of Pt(II) and Pd(II) with ethylsarcosinedithiocarbamate and 2-/3-picoline as antitumor agents", J. Inorg. Biochem. 99, (11), 2139–2150(2005).
L. Szucova, Z. Travnıcek and J. Marek," O,O Dialkyldithiophosphato and O-alkyldithiophosphato nickel(II) complexes with bidentate P-donor ligands", Polyhedron 22 pp 1341-/1348(2003).
L.Bolundut, I. Haiduc, E. Ilyes, G KociokKِhn, K. C. Molloy and S. GَmezRuiz, " Hydrogen bond supramolecular self-assembly in nickel(II) dithiophosphates, Ni[S2P(OR)2]2, R = sec-Bu, iso-Bu, and their bis(pyrazole) adducts", Inorg. Chim. Acta. 363, pp 4319–4323(2010).
F. Jian, K. Jiao, Q.Wang and H.Wang, " Synthesis and crystal structure of trans-bis(o,odiisopropylthiophosphoryl-1H-imidazole-N3)bis(o,odiisopropyldithiophosphato) nickel(II) complex: Ni[N3ImSP(OiPr)2]2 [S2P(OiPr)2]2 (Im = imidazole; iPr = isopropyl)", J. Chem. Crystallo., 34, (2), (2004).
A. K. Molodkin, N. Ya. Esina, O. I. Andreeva, and M. Konde, " Mixed-Ligand Platinum(IV) Complexes with amino acids and cytosine", Russi. J. Inorg. Chem., 53, (8), 1295–1303,(2008).
M. B.Tarallo, A.J. C. Filho, E. D. Vieira, A.Monge, C.Q. Leite, F.R.Pavan, G. Borthagaray, D.Gambino, M. H. Torre, "Research of new mixed-chelate copper complexes with quinoxaline N1,N4-dioxide derivatives and alanine as ligands, potential antimycobacterial agents".97,(1),80-89 (2009).
A. Caubet, V. Moreno, E.Moins and C. Miravitiies," Methionine and histidine Pd(II) and Pt(II) complexes: crystal structures and spectroscopic properties"J. Inorg. Biochem., 48, 135-152 (1992).
A. Iakovidis and N. Hadjiliadis," Complex compounds of platinum (II) and (IV) with amino acids, peptides and their derivatives", Coord. Chem. Rev., 135-136, P.17,(1994).
Browse journals by subject