Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading

Jiaxin Zuo; Jing Guo

doi:doi:10.11648/j.sjac.20221002.13

| Peer-Reviewed

Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading

Jiaxin Zuo, Jing Guo

Published in Science Journal of Analytical Chemistry (Volume 10, Issue 2)

Received: 16 May 2022 Accepted: 6 June 2022 Published: 14 June 2022

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Nitrite and edible salt are easy to confuse for their similar appearance and taste, thus possibly causing nitrite poisoning. Therefore, it is particularly crucial to figure out how to screen high concentrations of nitrite, how to discriminate NaNO₂ and NaCl, and how to accurately quantify high concentrations of nitrite. In this study, the phenomenon of high concentrations of nitrite fading to orange-yellow color in colorimetric solution of naphthalene ethylenediamine hydrochloride was studied and accurately quantified by dilution colorimetry. It is to prevent false negative detection while NaCl presented no such phenomenon. Through spectrophotometry, high-performance liquid chromatography, and liquid mass spectrometry, we discovered that the principle of high concentrations of nitrite fading to orange-yellow after colorimetry was that high concentrations of nitrite nitrosated azo compounds and naphthalene ethylenediamine hydrochloride in hydrochloric acid medium. This principle can make the solution appear orange-yellow while had almost no matrix interference and this demonstrates no difference in food and water. We thus argue that this principle can be used for the screening of high concentrations of nitrite, and discriminating NaNO₂ and NaCl to prevent poisoning events caused by misuses. In this sense, we believe the principle in question has a high applying value and is worth promoting. It can be made into a commercial hydrochloric acid acidified naphthylethylenediamine hydrochloride solution for further commercialized applications.

Published in	Science Journal of Analytical Chemistry (Volume 10, Issue 2)
DOI	10.11648/j.sjac.20221002.13
Page(s)	29-39
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nitrite, Discoloration, Study, Application

References

[1]	Shan, D. L., Wang, Y. L., Wang, Y. F., Lu, X. Q. (2017). Electrochemical Sensing Research on Nitrite by zirconium dioxide/graphene composites. Chin J. Anal. Chem; Vol. 45 No. 4; 502-507.
[2]	Chiesa, L., Arioli, F., Pavlovic, R., Villa, R. (2019). Detection of nitrate and nitrite in different seafood. Panseri S. Food Chem. 288, 361-367.
[3]	Jia, J., Lu, W. J., Li, L., Jiao, Y., Gao, Y. F., Shuang, S. M. (2019). Orange fluorescent carbon dots for nitrite detection. Chin J. Anal. Chem; Vol. 47 No. 4; 560-566.
[4]	Xiang, G. Q., Wang, Y. L., Zhang, H., Fan, H. H., Fan, L., He, L. J., Jiang, X. M., Zhao, W. J. (2018). Carbon dots based dual-emission silica nanoparticles as ratiometric fluorescent probe for nitrite determination in food samples. Food Chem. 260, 13-18.
[5]	Mónica Flores, Fidel Toldrá. (2021). Chemistry, safety, and regulatory considerations in the use of nitrite and nitrate from natural origin in meat products - Invited review. Meat Science. 171, 1-12.
[6]	Li, L. B., Liu, D., Wang, K. Mao, H. P., You, T. Y. (2017). Quantitative detection of nitrite with N-doped graphene quantum dots decorated N-doped carbon nanofibers composite-based electrochemical sensor. Sens. Actuators B. 252, 17-23.
[7]	Mao, Y., Bao, Y., Han, D. X., Zhao, B. (2018). Research Progress of Nitrite Electrochemical Sensors. Anal. Chem; Vol. 46 No. 2; 147-156.
[8]	Nesterenko, E. P., Murphy, B., Murray, E., Moore, B., Diamond, D. (2016). Solid-phase test reagent for determination of nitrite and nitrate. Anal. Methods; Vol. 8 No. 35; 6520-6528.
[9]	Erkekoglu, P., & Baydar, T. (2010). Nitrite a hidden foe in foods: Evaluation of nitrite in toxicological perspective. Gazi University Journal Science. 23, 261–270.
[10]	Titov, V. Y., Petrenko, Y. M. (2005). Proposed mechanism of nitrite-induced methemoglobinemia. Biochemistry; Vol. 70 No. 4; 473-483.
[11]	Aschengrau, A., Zierler, S., Cohen, A. (1989). Quality of community drinking water and the occurrence of spontaneous abortion. Arch. Environ. Health-Int. J.; Vol. 44 No. 5; 283-290.
[12]	Brender, J. D., Werler, M. M., Kelley, K. E., Vuong, A. M., Shinde, M. U., Zheng, Q., Huber, J. C., Sharkey, J. R., Griesenbeck, J. S., Romitti, P. A., Langlois, P. H., Suarez, L., Canfield, M. A. (2011). Nitrosatable drug exposure during early pregnancy and neural tube defects in offspring: National Birth Defects Prevention Study. Am. J. Epidemiol.; Vol. 174 No. 11; 1286-1295.
[13]	Zan, M. H., Rao, L., Huang, H. M., Xie, W., Zhu, D. M., Li, L., Qie, X. W., Guo, S. S., Zhao, X. Z., Liu, W., Dong, W. F.(2018). A strong green fluorescent nanoprobe for highly sensitive and selective detection of nitrite ions based on phosphorus and nitrogen co-doped carbon quantum dots. Sens. Actuators B. 262, 555-561.
[14]	Zhang, C. Z., Gao, Y. M., Li, H. X. (2021). Investigation on an outbreak of foodborne disease caused by accidental eating of nitrite. Prev Med Trib; Vol. 27 No. 11; 871-873.
[15]	Liu, M., Huang, X. G., Cao, J. (2008). A laboratory detection of nitrite food poisoning. Chin J. Modern Doc; Vol. 46 No. 14; 117-118.
[16]	Wang, B. (2020). Investigation and analysis of a food-borne nitrite poisoning incident. J. Occup. Health Damage; Vol. 35 No. 2; 101-103.
[17]	Ma, J. J., Wang, S., Jing, X. B. (2021). First aid and management of sudden nitrite group poisoning events during novel coronavirus pneumonia. J of Nur and Reh; Vol. 20 No. 8; 88-90.
[18]	Jiang, X., Jin, H. H., Zhang, Z. F. (2021). A laboratory detection and analysis of nitrite food poisoning. Anhui J. Prev Med; Vol. 27 No. 2; 151-152, 161.
[19]	Chen, X. R., Jia, W. H., Yang, C. L. (2015). Investigation and analysis of a case of food poisoning caused by accidental ingestion of nitrite. Chin J. of PHM; Vol. 31 No. 2; 160-161.
[20]	Che, S. L., Yin, L. J., Pei, Y. D. (2016). Investigation report on nitrite food poisoning incidents caused by bagged salt. J of Dis Mon and Con; Vol. 10 No. 3; 179-180.
[21]	Lv, J. P. (2015). An investigation report on food poisoning caused by accidental ingestion of nitrite. Anhui J. Prev Med; Vol. 21 No. 4; 303-304.
[22]	Xu, Z., Liang, J., Li, C. (2017). Investigation on a food-borne acute nitrite poisoning incident. Strait J. Prev Med; Vol. 23 No. 1; 88-90.
[23]	Xu, S. Q. (2016). An investigation report of nitrite poisoning caused by eating braised food. Chin J. Health Lab Tec; Vol. 26 No. 23; 3467-3468.
[24]	GB 2760-2014, National Food Safety Standard Standards of Using Food Additives. National Standards of the People’s Republic of China.
[25]	GB 5009.33-2016, National Food Safety Standard Determination of Nitrite and Nitrate in Foods. National Standards of the People’s Republic of China.
[26]	Dong, Y. H., CAO, L. L., Guo, J. (2001). Analysis of the colorimetric result of N-1-Naphthylethylenediamine colorimetric determination of high concentration nitrite. Chin J. of PH; Vol. 17 No. 10; 932.
[27]	Lu, C. Y., Li, S., Liu, P., Wang, S. H. (2017). Physical and Chemical Examination of Air [M]. Beijing: People's Medical Publishing House; 157.
[28]	Kevin, T. Kane, James, M., Smith, Kent, A. Peterson et al. (2000). Organic chemistry [M]. Boston Burr Ridge, IL Dubuque, IA Madison et al: university of virginia; 891.

Cite This Article

Plain Text BibTeX RIS

APA Style

Jiaxin Zuo, Jing Guo. (2022). Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading. Science Journal of Analytical Chemistry, 10(2), 29-39. https://doi.org/10.11648/j.sjac.20221002.13

Copy | Download

ACS Style

Jiaxin Zuo; Jing Guo. Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading. Sci. J. Anal. Chem. 2022, 10(2), 29-39. doi: 10.11648/j.sjac.20221002.13

Copy | Download

AMA Style

Jiaxin Zuo, Jing Guo. Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading. Sci J Anal Chem. 2022;10(2):29-39. doi: 10.11648/j.sjac.20221002.13

Copy | Download

@article{10.11648/j.sjac.20221002.13,
  author = {Jiaxin Zuo and Jing Guo},
  title = {Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading},
  journal = {Science Journal of Analytical Chemistry},
  volume = {10},
  number = {2},
  pages = {29-39},
  doi = {10.11648/j.sjac.20221002.13},
  url = {https://doi.org/10.11648/j.sjac.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjac.20221002.13},
  abstract = {Nitrite and edible salt are easy to confuse for their similar appearance and taste, thus possibly causing nitrite poisoning. Therefore, it is particularly crucial to figure out how to screen high concentrations of nitrite, how to discriminate NaNO2 and NaCl, and how to accurately quantify high concentrations of nitrite. In this study, the phenomenon of high concentrations of nitrite fading to orange-yellow color in colorimetric solution of naphthalene ethylenediamine hydrochloride was studied and accurately quantified by dilution colorimetry. It is to prevent false negative detection while NaCl presented no such phenomenon. Through spectrophotometry, high-performance liquid chromatography, and liquid mass spectrometry, we discovered that the principle of high concentrations of nitrite fading to orange-yellow after colorimetry was that high concentrations of nitrite nitrosated azo compounds and naphthalene ethylenediamine hydrochloride in hydrochloric acid medium. This principle can make the solution appear orange-yellow while had almost no matrix interference and this demonstrates no difference in food and water. We thus argue that this principle can be used for the screening of high concentrations of nitrite, and discriminating NaNO2 and NaCl to prevent poisoning events caused by misuses. In this sense, we believe the principle in question has a high applying value and is worth promoting. It can be made into a commercial hydrochloric acid acidified naphthylethylenediamine hydrochloride solution for further commercialized applications.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading
AU  - Jiaxin Zuo
AU  - Jing Guo
Y1  - 2022/06/14
PY  - 2022
N1  - https://doi.org/10.11648/j.sjac.20221002.13
DO  - 10.11648/j.sjac.20221002.13
T2  - Science Journal of Analytical Chemistry
JF  - Science Journal of Analytical Chemistry
JO  - Science Journal of Analytical Chemistry
SP  - 29
EP  - 39
PB  - Science Publishing Group
SN  - 2376-8053
UR  - https://doi.org/10.11648/j.sjac.20221002.13
AB  - Nitrite and edible salt are easy to confuse for their similar appearance and taste, thus possibly causing nitrite poisoning. Therefore, it is particularly crucial to figure out how to screen high concentrations of nitrite, how to discriminate NaNO2 and NaCl, and how to accurately quantify high concentrations of nitrite. In this study, the phenomenon of high concentrations of nitrite fading to orange-yellow color in colorimetric solution of naphthalene ethylenediamine hydrochloride was studied and accurately quantified by dilution colorimetry. It is to prevent false negative detection while NaCl presented no such phenomenon. Through spectrophotometry, high-performance liquid chromatography, and liquid mass spectrometry, we discovered that the principle of high concentrations of nitrite fading to orange-yellow after colorimetry was that high concentrations of nitrite nitrosated azo compounds and naphthalene ethylenediamine hydrochloride in hydrochloric acid medium. This principle can make the solution appear orange-yellow while had almost no matrix interference and this demonstrates no difference in food and water. We thus argue that this principle can be used for the screening of high concentrations of nitrite, and discriminating NaNO2 and NaCl to prevent poisoning events caused by misuses. In this sense, we believe the principle in question has a high applying value and is worth promoting. It can be made into a commercial hydrochloric acid acidified naphthylethylenediamine hydrochloride solution for further commercialized applications.
VL  - 10
IS  - 2
ER  -

Copy | Download

Author Information

Jiaxin Zuo

Hunan Center for Disease Control and Prevention, Changsha, China
Jing Guo

Hunan Provincial Finance and Trade Hospital, Changsha, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Jiaxin Zuo, Jing Guo. (2022). Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading. Science Journal of Analytical Chemistry, 10(2), 29-39. https://doi.org/10.11648/j.sjac.20221002.13

Copy | Download

ACS Style

Jiaxin Zuo; Jing Guo. Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading. Sci. J. Anal. Chem. 2022, 10(2), 29-39. doi: 10.11648/j.sjac.20221002.13

Copy | Download

AMA Style

Jiaxin Zuo, Jing Guo. Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading. Sci J Anal Chem. 2022;10(2):29-39. doi: 10.11648/j.sjac.20221002.13

Copy | Download

@article{10.11648/j.sjac.20221002.13,
  author = {Jiaxin Zuo and Jing Guo},
  title = {Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading},
  journal = {Science Journal of Analytical Chemistry},
  volume = {10},
  number = {2},
  pages = {29-39},
  doi = {10.11648/j.sjac.20221002.13},
  url = {https://doi.org/10.11648/j.sjac.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjac.20221002.13},
  abstract = {Nitrite and edible salt are easy to confuse for their similar appearance and taste, thus possibly causing nitrite poisoning. Therefore, it is particularly crucial to figure out how to screen high concentrations of nitrite, how to discriminate NaNO2 and NaCl, and how to accurately quantify high concentrations of nitrite. In this study, the phenomenon of high concentrations of nitrite fading to orange-yellow color in colorimetric solution of naphthalene ethylenediamine hydrochloride was studied and accurately quantified by dilution colorimetry. It is to prevent false negative detection while NaCl presented no such phenomenon. Through spectrophotometry, high-performance liquid chromatography, and liquid mass spectrometry, we discovered that the principle of high concentrations of nitrite fading to orange-yellow after colorimetry was that high concentrations of nitrite nitrosated azo compounds and naphthalene ethylenediamine hydrochloride in hydrochloric acid medium. This principle can make the solution appear orange-yellow while had almost no matrix interference and this demonstrates no difference in food and water. We thus argue that this principle can be used for the screening of high concentrations of nitrite, and discriminating NaNO2 and NaCl to prevent poisoning events caused by misuses. In this sense, we believe the principle in question has a high applying value and is worth promoting. It can be made into a commercial hydrochloric acid acidified naphthylethylenediamine hydrochloride solution for further commercialized applications.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Study on Mechanism and Application of High Concentrations of Nitrite-Induced Specific Color Fading
AU  - Jiaxin Zuo
AU  - Jing Guo
Y1  - 2022/06/14
PY  - 2022
N1  - https://doi.org/10.11648/j.sjac.20221002.13
DO  - 10.11648/j.sjac.20221002.13
T2  - Science Journal of Analytical Chemistry
JF  - Science Journal of Analytical Chemistry
JO  - Science Journal of Analytical Chemistry
SP  - 29
EP  - 39
PB  - Science Publishing Group
SN  - 2376-8053
UR  - https://doi.org/10.11648/j.sjac.20221002.13
AB  - Nitrite and edible salt are easy to confuse for their similar appearance and taste, thus possibly causing nitrite poisoning. Therefore, it is particularly crucial to figure out how to screen high concentrations of nitrite, how to discriminate NaNO2 and NaCl, and how to accurately quantify high concentrations of nitrite. In this study, the phenomenon of high concentrations of nitrite fading to orange-yellow color in colorimetric solution of naphthalene ethylenediamine hydrochloride was studied and accurately quantified by dilution colorimetry. It is to prevent false negative detection while NaCl presented no such phenomenon. Through spectrophotometry, high-performance liquid chromatography, and liquid mass spectrometry, we discovered that the principle of high concentrations of nitrite fading to orange-yellow after colorimetry was that high concentrations of nitrite nitrosated azo compounds and naphthalene ethylenediamine hydrochloride in hydrochloric acid medium. This principle can make the solution appear orange-yellow while had almost no matrix interference and this demonstrates no difference in food and water. We thus argue that this principle can be used for the screening of high concentrations of nitrite, and discriminating NaNO2 and NaCl to prevent poisoning events caused by misuses. In this sense, we believe the principle in question has a high applying value and is worth promoting. It can be made into a commercial hydrochloric acid acidified naphthylethylenediamine hydrochloride solution for further commercialized applications.
VL  - 10
IS  - 2
ER  -

Copy | Download